Maximal Testosterone Suppression in Prostate Cancer—Free vs Total Testosterone

Testosterone suppression by heroin.

Determined Free Serum Testosterone is Better than Total Testosterone as a Predictor of Prostate Cancer Risk

Background: Circulating testosterone remains the main source of androgens, however only 1%-2% circulates as free testosterone (fT), hormone active form. To compare the performance of serum fT and total testosterone (tT) as predictors of prostate cancer (PCa) detection and aggressiveness. Methods: Serum fT (RIA, pg/mL) and tT (LC/MS, ng/dL) were prospectively determined in 3364 consecutive men w...

Serum Testosterone Level, Testosterone Replacement Treatment, and Prostate Cancer

There has been an increase in the number of individuals seeking testosterone (T) replacement treatment (TRT) due to a decrease in their blood T levels. Prostate cancer (PCa) is also an important issue in the same age group. However, we, urologists, are anxious about PCa development after T treatment. This is because it has been assumed that T may cause PCa or exacerbate insidious PCa which is a...

Analog-based free testosterone test results linked to total testosterone concentrations, not free testosterone concentrations.

BACKGROUND Analog-based free testosterone test results, sex hormone binding globulin (SHBG) concentrations, and total testosterone concentrations are somehow related. This study used new experiments to clarify these relationships. METHODS An analog-based free testosterone immunoassay and a total testosterone immunoassay were applied to well-defined fractions of serum testosterone. First, they...

Testosterone Substitution and the Prostate

Testosterone substitution is reported to produce a wide range of benefits for men with hypogonadism that include improvements in muscle mass, body composition, mood, bone density, libido, and cognition. Understanding the actions of exogenous testosterone on the prostate gland is important since testosterone is the major regulator of growth and function of this organ. To date, clinical studies o...